REF 37. Regulatory Toxicology

Fundamentals and application within the REACH/BPR framework

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Aimed at

Manufacturers/importers of substances/mixtures, downstream users including formulators and distributors, and end users of substances/mixtures.

Objectives

Introduction to the fundamental concepts of toxicology
Application in the regulatory field
Overview of traditional experimental methods in regulatory toxicology

Contents

1. Introduction to Toxicology

1.1. Introduction

Concepts: acute, sub-chronic, chronic
The dose-response concept. Application in regulatory contexts.

1.2. Toxicology in REACH/BPR

Key toxicological aspects in REACH/BPR

2. Toxicological parameters

2.1. Review of the data required under REACH/BPR

2.2. Physicochemical data – Critical parameters

Water solubility, Partition coefficient. Vapour pressure

2.3. Toxicity in mammals

Brief description of the main laboratory tests
Skin irritation or skin corrosion. Skin sensitisation
Acute toxicity
Repeated-dose toxicity
Mutagenicity. Carcinogenicity study. Reproductive toxicity

2.4. Ecotoxicity

Aquatic toxicity. Degradation
Fate and behaviour in the environment

Course details

Duration: 6 hours
Date: 11 June 2026
Time: 08:30 to 14:30
Venue: Virtual Classroom

Cost

Per person: €795 + VAT
Subsidised course: €717 + VAT (approx.)